His Recommended Longevity Essentials
Professor David Sinclair, the renowned Harvard geneticist and longevity researcher, has pioneered groundbreaking work on cellular ageing and NAD+ metabolism. His evidence-based approach to longevity has inspired millions to rethink how we age, not as an inevitable decline, but as a biological process that can potentially be influenced through targeted interventions.
At Healthspan Formulas, we've developed premium supplements that align with the key compounds featured in Sinclair's research and personal protocol, making this cutting-edge science accessible to everyone committed to optimising their healthspan.
Understanding the Sinclair Protocol: Key Supplements
Nicotinamide Mononucleotide (NMN)
The cornerstone of Sinclair's approach is NMN, a direct precursor to NAD+—a coenzyme that declines with age and plays a critical role in cellular energy production and repair mechanisms.
Sinclair has discussed taking approximately 1 gram of NMN daily, split into morning and evening doses. He specifically notes the importance of quality and bioavailability when selecting NMN supplements.
Resveratrol
Sinclair's research has extensively focused on resveratrol, particularly its ability to activate sirtuins—proteins that regulate cellular health and are associated with longevity pathways.
In his protocol, resveratrol is typically taken in the morning with yogurt or a fat-containing food to enhance absorption.
Supporting Nutrients: TMG and Vitamin B Complex
Methyl donors like Trimethylglycine (TMG) are often recommended alongside NAD+ precursors to support methylation processes. Additionally, a comprehensive B vitamin complex, including methylated forms like B12 (methylcobalamin), supports energy metabolism and overall cellular function.
Our Premium David Sinclair-Inspired Supplements
Nicotinamide Mononucleotide (NMN)
Our pharmaceutical-grade NMN delivers 500mg per capsule in a delayed-release format for optimal absorption. This premium supplement provides the cornerstone molecule in Sinclair's longevity approach.
NMN & TMG Complex
This comprehensive formula combines six key compounds featured in longevity research:
- NMN (β-Nicotinamide Mononucleotide) - The direct NAD+ precursor
- Trimethylglycine (TMG) - Supports healthy methylation
- Quercetin - A potent flavonoid with antioxidant properties
- Pterostilbene - An enhanced bioavailable analogue of resveratrol
- Trans-Resveratrol - The sirtuin-activating compound extensively studied by Sinclair
- Vitamin B12 (Methylcobalamin) - The premium form for optimal utilization
Longevity Essentials Bundle
This science-backed duo combines the two most researched compounds in Sinclair's work:
- 500mg NMN (60 capsules) - The direct NAD+ precursor
- 150mg Resveratrol (90 capsules) - The sirtuin activator
This carefully calibrated combination mirrors the core supplementation approach discussed by Sinclair in his research and public communications.
The Science Behind These Supplements
NAD+ Restoration
"NAD+ is the closest we've gotten to a fountain of youth," Sinclair has noted in his research publications. As we age, NAD+ levels naturally decline—by age 50, we typically have about half the NAD+ we had in our youth.
NMN supplementation aims to restore these levels by providing the direct precursor molecule that converts to NAD+ through the most efficient pathway.
Sirtuin Activation
Sinclair's groundbreaking research has focused extensively on sirtuins—proteins that regulate cellular health and DNA repair. Resveratrol has been shown to activate SIRT1, potentially mimicking some of the cellular benefits of caloric restriction.
The Synergistic Approach
The most compelling aspect of Sinclair's protocol is the synergistic relationship between NMN and resveratrol. NMN helps boost NAD+ levels (the fuel), while resveratrol activates sirtuins (the engines) that utilize NAD+ to drive cellular rejuvenation processes.
How to Implement a Sinclair-Inspired Protocol
For those looking to follow a supplement regimen inspired by Sinclair's approach, we recommend:
Morning Routine:
- 500mg NMN or NMN+TMG Complex
- 150mg Resveratrol (ideally with a small amount of fat for better absorption)
Evening Routine:
- 500mg NMN (optional second dose for enhanced support)
Consistent Implementation:
- Regular, daily supplementation appears to be key to the approach
- Allow 4-6 weeks for potential effects to become noticeable
When selecting supplements aligned with Sinclair's research, quality is paramount. Our products feature:
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Pharmaceutical-Grade Purity: Each ingredient meets rigorous quality standards
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Optimised Bioavailability: Delayed-release technology for NMN and proper formulation for resveratrol
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Synergistic Formulations: Carefully calibrated combinations of complementary compounds
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UK-Made Excellence: Manufactured in GMP-certified facilities
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Evidence-Based Approach: Formulations informed by peer-reviewed research
Important Considerations
While Sinclair's protocol has generated significant scientific interest, it's important to note:
- Individual results may vary
- Supplements should complement, not replace, other healthy lifestyle practices
- Consult with healthcare providers before beginning any new supplement regimen
- The field of longevity research continues to evolve
Experience the Science of Longevity
Whether you're already familiar with Sinclair's work or just beginning to explore evidence-based approaches to healthy ageing, our premium supplements provide the quality and potency to support your longevity journey.
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Note: David Sinclair is not associated with this range or Healthspan Formulas, we simply curated this range based on his recommendations and protocols.
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